Can You Take CBD Oil With Cymbalta


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Contributor: Dr. Augustine Provencio, MD CBD and Cymbalta explained. When finding treatment for common illnesses like chronic pain and anxiety, the search Can CBD oil be taken with Cymbalta? Here's the general view and exceptions in which a doctor can prescribe both. Plus what each does and the side effects. Your access to this site has been limited by the site owner If you think you have been blocked in error, contact the owner of this site for assistance. If you are a WordPress user with

CBD and Cymbalta

CBD and Cymbalta explained. When finding treatment for common illnesses like chronic pain and anxiety, the search for a substance that works can be frustrating to patients, and in cases, worsen already existing side effects.

Cymbalta, also known as Duloxetine, is a prescription medication used to treat symptoms of anxiety, depression, and Fibromyalgia. CBD, another well know substance, is paving the way as a new revolutionary drug to help treat a variety of diseases. Here we will discuss CBD and its reaction / potential side effects when mixed with Cymbalta.

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What Does Cymbalta Treat

Anxiety and depression affect the sufferers physical and emotional responses to stressors and stimuli, often creating negative (and in many cases involuntary) responses to seemingly insignificant triggers. Fibromyalgia, or a tight pain in muscles and pressure points throughout the body, can be both caused by and cause anxiety-like symptoms.

Why Compare Cymbalta and CBD

Some patients using Cymbalta have begun to look to CBD as a method of increasing the positive effects of the drug such as pain and anxiety relief, or in other cases hope that the addition of CBD will make it possible to lower or change their Cymbalta dosage with less harsh side effects. Navigating the dosage and alteration of treatment can be tricky, which has raised questions of just how effective CBD is in relation to Cymbalta and whether or not pairing the two is a safe choice. CBD has been observed to help patients with both anxiety and pain, prompting closer examination of the interactions CBD can have with Cymbalta.

How Does Cymbalta Work Chemically

Cymbalta, similar to CBD, interacts with the Serotonin centers in the brain. Cymbalta is a serotonin-norepinephrine reuptake inhibitor. The delayed release capsules stimulate serotonin centers which help to create a calming effect and elevate mood. Specifically, Cymbalta prevents brain cells from quickly absorbing neurotransmitters and sending overactive messages of panic and fear to the body known as fight or flight responses. These responses include symptoms of both anxiety and Fibromyalgia. Muscle pain and tension typical to Fibromyalgia sufferers can be brought about by panic attacks.

How Does CBD Work Chemically

CBD functions in a similar way to Cymbalta, working with receptors that trigger fear responses and bodily reactions (muscle tension, headaches etc.) By interacting with the parts of the brain responsible for symptoms of anxiety and Fibromyalgia, substances like Cymbalta can lessen the severity of these symptoms. Many CBD users have have reported to notice relief for these same symptoms from using CBD oil.

Possible Side Effects of Cymbalta

A major concern in mixing CBD and Cymbalta is how CBD can exasperate already possible negative side effects. Side effects largely depend on the individual patient, their chemical makeup, and what Cymbalta is prescribed to them for. These side effects include:

  • Nusea
  • Dry Mouth
  • Fatigue
  • Loss of Appetite
  • Sweating
  • Increased anxiety or panic attacks
  • Increased depression
  • Suicidal thoughts

Other Cymbalta Concerns

Some patients prescribed Cymbalta have reported withdrawal symptoms after stopping the medication. This reaction is not uncommon after discontinuation of depression and anxiety medications, which is another strong reason that some patients have begun to try CBD. CBD oil can help with withdrawal effects while presenting no withdrawal effects of its own. Read more about patients reports on Cymbalta withdraws here.

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How Do CBD and Cymbalta Interact

Some observations have noticed moderate interaction between CBD / Cannabis products and Cymbalta. While there are no fatal or extremely internally hazardous interactions noted to date, CBD and Cymbalta can cause complications when used together for the treatment of anxiety or chronic pain. Among these interactions are:

  • Dizziness
  • Confusion
  • Lack of Concentration
  • Impaired Judgement
  • Loss of memory

These symptoms are noted to be worse in elderly users.

Mixing Cymbalta and CBD

In terms of mixing CBD and Cymbalta for anxiety, it may be helpful for cases of insomnia (or sleeplessness brought on by moderate to severe pain) but presents risks for users when functioning through normal daily activities. CBD and Cymbalta together present largely sedative interactions.

Studies of CBD and Fibromyalgia

Fibromyalgia is one of the main ailments Cymbalta is prescribed for. Though CBD and Cymbalta are not extremely beneficial together, patients concerned about potential withdrawal from Cymbalta do have the option of turning to CBD as an alternative medication. A recent study tested cannabis products against three Fibromyalgia medications including Cymbalta and found that 62% of patients tested found CBD to be a helpful treatment for chronic pain.

CBD as Long-term Pain Relief Alternative

Other patients who have not found relief in major FDA approved drugs have reported some positive findings when using CBD to tried their Fibromyalgia related pain. One user expressed that she did feel significant relief after years of searching, but did warn that buyers should closely monior the quality of the CBD they buy. Good CBD may be more expensive, but when taking the place of a larger drug like Cymbalta, the cost was worth it.


Taking CBD with Cymbalta has not been observed to have inherently lethal or harmful side effects, however, some of the side effects noted can make it difficult to perform daily tasks like driving, operating machinery, and making decisions. These interactions have been especially prominent in elderly users. When compared to Cymbalta as a treatment option for Fibromyalgia, users have found proportionately positive results. CBD offers a treatment that has been observed to be effective in treating pain while avoiding the difficult withdrawal symptoms some Cymbalta users have suffered.

How to Try Safely

Before making any changes to your treatment for anxiety, depression, or Fibromyalgia, it is important to consult your doctor and make your interest in CBD as an alternative known. Only a medical professional can properly help in balancing dosages and alerting you to and possible adverse reactions you may not have been aware of. As with any medication, figuring out the exact dose and frequency that will be most effective for your symptoms may take time, and communicating your goals, experiences, and preferences clearly with your doctor. As more studies are conducted on CBD as a treatment option, more possibilities become clear. If you have found little relief from taking Cymbalta, or are looking to make a change with less withdrawal symptoms, CBD may be an option to consider.

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Can CBD Oil Be Taken With Cymbalta? Here’s What Happens

If you’re asking can CBD oil be taken with Cymbalta, then you’re not alone. The use of CBD in oil, and other forms, has become more prevalent in recent years.

So, it’s not surprising that those taking Cymbalta are looking to understand its interactions with CBD products.

In this article, we’ve outlined what each does, how they work, and whether CBD oil can be taken with Cymbalta – and if so, when and how. Here’s a summary to give you a brief overview.

Can CBD oil be taken with Cymbalta? In general, CBD oil should not be taken with Cymbalta as it can intensify side effects in relation to cognitive process and motor skills. In severe cases, this can lead to serotonin syndrome and liver failure. Some see most side effects as moderate, and doctors can prescribe both.

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With that brief takeaway to give you a clear overview of the answer, it’s important to help you become familiar with both these medications and their side effects.

Only through this will it be easier to grasp why CBD oil can or cannot be taken with Cymbalta.

Cymbalta, CBD, and their side effects

In the lead-up to a more comprehensive answer, we’re going to recap on the significance of both Cymbalta and CBD and discover the similarities in which each operates and how both affect the body.


Cymbalta is an SNRI antidepressant. SNRI stands for serotonin-norepinephrine reuptake inhibitor.

What this medication essentially does is block serotonin and norepinephrine from being reabsorbed into your neurons.

Duloxetine is the main active ingredient of Cymbalta.

Cymbalta is used to treat:

  • Major depressive disorder
  • Generalized anxiety disorder
  • Fibromyalgia
  • Pain caused by diabetic neuropathy
  • Osteoarthritis pain
  • Chronic musculoskeletal pain

The common side effects of Cymbalta include:

  • Dry mouth
  • Loss of appetite
  • Dizziness and lightheadedness
  • Nausea
  • Constipation
  • Tiredness and drowsiness
  • Increased sweating
  • Increased blood pressure


CBD stands for cannabidiol. CBD oil is made by extracting CBD from the cannabis plant, then diluting it with a carrier oil like coconut or hemp seed oil.

While CBD is an essential component of the “marijuana plant,” it is derived from the hemp plant. Both plants belong to the same species, but the hemp plant contains 0.3 percent or less THC. Therefore, CBD does not contain THC, which is the psychoactive ingredient in marijuana.

CBD oil is used to treat:

  • Anxiety and depression
  • Insomnia
  • Chronic pain
  • Arthritis or joint pain
  • Epilepsy and other seizure disorders
  • Multiple sclerosis (MS)
  • Lung conditions
  • Sleep disorders
  • Nausea
  • Cancer
  • Allergies or asthma
  • Migraine
  • Cluster and other headaches
  • Post-traumatic stress disorder (PTSD)
  • Parkinson’s disease
  • Alzheimer’s disease

Common side effects of CBD oil include:

  • Dry mouth
  • Diarrhea
  • Weak appetite
  • Drowsiness
  • Fatigue
  • Irritability
  • Liver inflammation
  • Mood changes
  • Decrease in alertness.

Can CBD oil be taken with Cymbalta – the general view

As you can see, both CBD oil and Cymbalta are used for treating similar medical conditions, and equally, they exhibit many similar side effects.

So, essentially, if CBD oil is taken with Cymbalta, the side effects of each other could be magnified, resulting in more severe adverse reactions.

In scientific terms, when both these drugs interact, they can cause problems related to cognitive and motor function.

Cognitive problems include confusion, impaired judgment, concentration problems, and difficulty in thinking. Motor function problems include dizziness and impaired coordination.

Special circumstances

Some consider the side effects of taking CBD oil with Cymbalta – and their interactions – to be moderate.

It is also believed that doctors can recommend CBD oil to be taken with Cymbalta under special circumstances.

This is in situations in which your healthcare provider decides the benefits would likely outweigh the risk.

However, if such a combination is provided, your healthcare provider will need to closely monitor your side effects to ensure you are not at risk of severe adverse reactions.

So, from the perspective of absolute safety, CBD oil should not be taken with Cymbalta, as magnified side effects from taking both together can cause other potentially severe issues too, which we’ll cover below…

What happens if you take CBD oil with Cymbalta?

There are three main negative outcomes of taking CBD oil with Cymbalta. Below are those three outcomes in the order of least to most severe.

1. Intensified side effects

As we mentioned earlier, the primary negative result of taking CBD oil with Cymbalta is intensified side effects.

In this scenario, 80% of all pharmaceutical products are broken down in the liver. This action is performed by a group of enzymes called Cytochrome P450 (CYP450).

It’s the liver that breaks down both Cymbalta and the cannabinoids like CBD oil and THC.

This naturally means that when CBD oil is taken with Cymbalta, both of these compounds will compete for the enzyme cytochrome P450 (CYP450) in your liver for breaking them down and metabolizing them.

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This means that there is a slower rate of metabolizing them. Thus, the effect of each compound is longer and more potent.

The result of this could be exacerbated side effects.

2. Serotonin syndrome

Cymbalta specifically is a serotonin inhibitor that blocks serotonin from being absorbed into your system.

In safe doses, the blockage helps Cymbalta treat the conditions for which it’s been prescribed.

It’s believed that when you add a new drug to your regimen with Cymbalta or when you increase the dose of Cymbalta, it can easily cause “serotonin syndrome.”

Serotonin syndrome is when you have too much serotonin in your system, which could cause a range of side effects.

Some of these side effects include:

  • Agitation or restlessness
  • Confusion
  • Rapid heart rate and high blood pressure
  • Dilated pupils
  • Loss of muscle coordination or twitching muscles
  • Muscle rigidity
  • Heavy sweating
  • Diarrhea

3. Liver failure

This is the final and the most severe risk of taking CBD oil with Cymbalta. Liver failure results in loss of liver functions.

One main reason for liver failure includes overwhelming your liver function by combining medications or supplements like CBD oil and Cymbalta.

Liver failure occurs when your liver cells are damaged and they can no longer perform due to exhaustion.

Symptoms of liver failure include:

  • Nausea
  • Malaise (general sense of feeling unwell)
  • Sleepiness
  • Abdominal swelling
  • Jaundice (yellowing of your skin and eyeballs)
  • Vomiting
  • Disorientation

Exceptions for taking CBD oil with Cymbalta

Some believe that you can replace Cymbalta with CBD oil – and vice versa.

However, this is not scientifically proven and should only be undertaken through consultation with your healthcare provider.

To mitigate against potential problems, some also opt for methods such as:

  • Space out the time between taking CBD oil and Cymbalta (1 – 3 hours generally). This will prevent the drugs from overlapping with the effects of one another.
  • Microdose your cannabis therapy treatment. This is to practice taking the minimal amount of a given substance to achieve your desired results.
  • Slowly increase your cannabis therapy dosage over time. This is where you take your regular dose of Cymbalta and then slowly increase only the intake of CBD oil until the point you feel it’s tolerable or doesn’t reflect intense side effects.
  • Find and consult with a pro-cannabis medical professional. This is the best exception we can recommend. A CBD professional knows exactly how it can work for your body and condition. They may be able to offer dose advice or other strategies to take CBD oil with Cymbalta in such a way as not to intensify the side effects and exacerbate other related problems taking them together.

Again, these are only general guidelines and are NOT meant for official medical advice when taking CBD oil with Cymbalta. Always consult your healthcare provider before making any changes to your treatment.

Final thoughts

We hope this has armed you with what you need to know regarding the question can CBD oil be taken with Cymbalta. There are other ways in which Prescription Hope can assist you too…

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