CBD Oil And Magnesium For Sleep


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Will CBD interact with my magnesium supplements? We’ll explain the similarities between both and talk about the possible effects of their interaction. BEST supplements for sleep: Difficulty falling asleep affects most of us at some time, but are there certain vitamins, minerals or nutrients we can add to our diet ensure we get a peaceful forty winks? Can you take CBD together with magnesium? This article explains the potential interactions between these two supplements — and whether they can have a negative impact on your health.

Does CBD Interact With Magnesium?

Information on risks & possible interactions between CBD & magnesium.

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Cannabidiol or CBD is used in treating various conditions, including pain and inflammation. It’s been deemed safe for most illnesses.

Magnesium is a mineral supplement used for treating migraines, blood pressure, etc. It’s an essential mineral in the body.

Since both work very differently, there’s very little chance of these supplements interacting with each other. To date, there are no reported complaints about the effects of the interaction between CBD and magnesium.

Table of Contents

Does CBD Interact With Magnesium?

No, there have not been any documented reports about the side effects caused by taking both CBD and magnesium.

Magnesium may slow the absorption of CBD in the digestive tract, thus making it less effective.

To avoid this potential interaction, take magnesium supplements one or two hours apart from CBD supplements.

Is CBD a Viable Alternative to Magnesium?

CBD and magnesium are entirely different supplements. Magnesium is an essential mineral used in well over 300 enzymatic processes in the human body. CBD is a cannabinoid obtained from hemp that interacts with the endocannabinoid system.

You cannot use CBD as an alternative to magnesium for most applications.

However, CBD helps treat certain medical conditions that magnesium is used to treat.

If the cause of the condition is a magnesium deficiency, CBD will offer little benefit. But if the reason is something else, CBD may significantly help these conditions more than magnesium.

For this reason, it’s better to take both supplements for a more holistic effect than either one individually. Just make sure to separate the doses by about two hours to enable maximum absorption of both supplements.

Magnesium and CBD are commonly used for the following conditions:

1. Migraine Headaches

Magnesium is one of the most common supplements used for migraine headaches. Many people with migraines are deficient in magnesium; supplying supplemental magnesium can lower migraine headaches in patients [1].

CBD has also been proven effective for migraine sufferers and other forms of headaches, including hangovers and cluster headaches [2].

While it’s unlikely that CBD will reverse or prevent migraines directly, it may reduce the severity and duration and alleviate concomitant issues like vision disturbances, insomnia, and nausea or vomiting.

2. Depression & Anxiety

Magnesium levels are low in patients with major depression, so supplementing with it can lower the symptoms and help elevate mood in depressive patients [3].

CBD can work on the 5-HT1A neuro-receptors in the brain and works as an anxiolytic and antidepressant [4].

3. Cardiovascular Diseases

A study about CBD showed that it might help reduce oxidative stress and reduce cardiac dysfunction [6]. Its anti-inflammatory properties may also help lower the risk of cardiac diseases.

4. Insomnia

Magnesium can help improve insomnia symptoms due to it regulating the neurotransmitters directly related to the brain [7].

CBD may improve sleep and be more tolerated than routine sleep medications [8].

5. Type II Diabetes

Magnesium plays a vital role in controlling the breakdown of sugar in the body. Having a good amount of magnesium in the diet may help prevent the development of type II diabetes [9].

CBD can offer metabolic support through its interaction with the endocannabinoid system [10]. The ECS is intimately involved with liver and pancreas health — both of which play a key role in the pathophysiology of diabetes.

6. Bone Health

A lack of magnesium in the body can further lead to osteoporosis in the body [11]. To prevent this, supplementing with magnesium is necessary. It’s one of the most commonly recommended supplements for menopausal women for this reason.

CBD can offer improvements towards bone health through its role in regulating the endocannabinoid system [12].

7. Seizures & Epilepsy

Magnesium sulfate, a compound containing magnesium, has been used in treating seizures caused by conditions of pregnancy like eclampsia [13]. It’s a common supplement in magnesium deficiency.

CBD-based medications, including Sativex and Epidiolex, are approved to treat multiple types of seizure disorders [14].

What Is Magnesium?

Magnesium is an essential macromineral obtained from different kinds of foods, supplements, and medications. It’s taken in conditions such as magnesium deficiency, heartburn, constipation, arrhythmias called Torsades de Pointes, pre-eclampsia, eclampsia, and more.

This mineral is a cofactor in more than 300 separate enzymatic reactions within the body. These reactions range from cellular replication to liver metabolism — and everything in between.

Magnesium plays the role of helping with the functioning of the muscles and nerves, controlling blood pressure, helping the immune system, bone formation, and so much more.

Magnesium Specs:

Names Magnesium, magnesium oxide, magnesium sulfate, magnesium carbonate, magnesium chloride, magnesium citrate, magnesium malate, magnesium sulfate
Classification Essential Macromineral
Metabolism Kidney, intestines
Interaction with CBD Unknown, but likely no interaction
Risk of Interaction Unknown, but likely low

What Does Magnesium Do?

Magnesium is an essential cofactor needed in the operation of several bodily functions. It’s distributed between the bone, skeletal muscle, soft tissue, and extracellular fluids. The body regulates it through an interplay between intestinal absorption, absorption by the bone, and renal absorption or excretion.

Magnesium helps in ion transport and keeps the balance across cellular membranes. It competes in the calcium channels, affecting the uptake and release of calcium, and controls its metabolism.

It can stop the contraction caused by calcium in the smooth muscles and acetylcholine’s actions on the nerve and muscle junctions. This leads to the relaxing of the smooth muscles, which then helps to reduce spasms.

Magnesium assists more than 300 enzymes in carrying out different reactions in the body. It also acts as a cofactor for enzymatic actions in various activities. It helps build proteins, regulate blood sugar, build bones, control blood pressure and maintain muscle and nerve health.

It can help control the actions of N-methyl-D-aspartate (NMDA) glutamate receptors, the ones needed for memory forming and learning. An excess action of glutamate in the brain can cause seizures, anxiety, and depression. It blocks the action of glutamate in the NMDA receptors; thus, it may prevent or treat depression.

The deficiency of magnesium in the diet can cause several symptoms, such as numbness, tingling, muscle cramps, nausea, vomiting, and headaches.

Magnesium is used to treat migraines, acute nephritis, cardiac arrhythmias due to hypomagnesemia, seizures caused by eclampsia, as a laxative for constipation, and antacid for heartburn.

Side Effects of Magnesium

  • Facial flushing
  • Stomach upset
  • Tingling sensation
  • Nausea
  • Vomiting
  • Diarrhea
  • Weakness
  • Overactive reflexes
  • Muscle depression

Types of Drug Interactions With CBD

Several studies have shown the efficacy of CBD in the treatment of many different diseases.

These effects happen due to the chemical nature of these medications. Thus taking other drugs with CBD must be supervised carefully as any interaction could lead to complications of various kinds.

There are three ways that CBD can interact with other drugs, including:

1. Agonistic Interaction

This interaction means that two medicines both show the same effect in the body. When consumed together, these medications may act on the same or different receptors. But they show effects in the same direction.

The medications that could bring about agonistic interaction on taking with CBD are:

  • Antihypertensive Medications — These include ACE inhibitors, alpha-blockers, angiotensin II receptor blockers, beta-blockers, calcium channel blockers, central agonists, and diuretics. CBD can react with these causing a drop in blood pressure, dizziness, and fainting.
  • Anti-anxiety medications — These include common prescriptions like benzodiazepines and barbiturates. CBD could make the effects of these medications last longer than normal.
  • Antidiabetic medications — These include GLP-1 receptor agonists, meglitinides, SGLT-2 inhibitors, sulfonylureas, and insulin, alpha-glucosidase inhibitors, biguanides, DPP-4 inhibitors.

2. Antagonistic Interaction

This is the opposite of the agonistic interaction. Antagonistic interaction happens when two drugs have effects opposite of each other. If taken together, one drug would invalidate the effects of the other, leading to a decrease in its efficacy.

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Drugs that have antagonistic interaction with CBD are:

  • Stimulants — These include amphetamine, modafinil. CBD can negate the effects of these drugs.
  • Immunomodulators — These include antihistamines like carbinoxamine, desloratadine, levocetirizine. The sedative action of CBD could worsen the side effects of immunomodulators.
  • Immunosuppressants — These include azathioprine, mycophenolate cyclosporine, methotrexate, etc. CBD’s immune-stimulating properties may negate the effects of immunosuppressants.
  • Asthma Medications — These include drugs like albuterol, fluticasone, montelukast, ipratropium bromide, theophylline. CBD may counteract the actions of these medications and can speed up theophylline’s excretion from the body.

3. Metabolic Inhibition

Some medications need similar enzymes to break down the drug molecules. It leads to both drugs competing against each other. It then causes a slowdown in the metabolism rate for both of them.

These include medications like:

  • Blood Thinners — CBD could lead to an increase in the action of warfarin, enoxaparin, heparin, and others that could be potentially dangerous.
  • NSAIDs — These include ibuprofen, naproxen, high-dose aspirin. CBD could cause these drugs to last longer in the bloodstream.
  • Opiate Analgesics — These include morphine, codeine, and hydrocodone. CBD could compete with these in the liver leading to a chance of overdose.
  • Antidepressants —These include trazodone, mirtazapine, vortioxetine, and vilazodone, and others. CBD could slow down their metabolism and lead to the buildup of these drugs in the body.

Key Takeaways: Is It Safe to Take Magnesium With CBD?

Magnesium and CBD work differently and, theoretically, should have minimal to no interactions between them.

However, there’s no reported documentation of the side effects by users who have used them together, and there is a lack of proper clinical trials and studies.

If you take regular magnesium supplements to treat a specific medical disorder, you should speak with your doctor before taking CBD.

If you’re using magnesium supplements as a general health-promoting supplement, there’s little to no risk of taking CBD alongside it. However, it’s best to take both supplements about two hours apart to ensure maximum absorption of both substances.

If you feel any adverse side effects after taking CBD and magnesium, stop taking them immediately. If symptoms persist, visit your physician.

Best supplements for sleep: Six natural remedies to ensure a good night’s rest

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Sleep problems often occur during periods of street when anxiety makes it difficult to relax.

But not getting enough sleep can be detrimental to a person’s health.

Making changes to your sleep environment is often recommended, such as making sure the room you sleep in is cool, quiet and dark.

But some experts say supplements can help assist uninterrupted sleep. Dr Sarah Brewer recommends six supplements for you to try.

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Some experts say supplements can help assist uninterrupted sleep

CBD oil

CBD (cannabidiol) oil is Dr Brewer’s own sleep-promoting supplement of choice.

She said: “CBD is a natural extract from industrial hemp plants which is relaxing, lifts mood and generates feelings of wellbeing.

“CBD enhances the effects of brain chemicals such as serotonin and anandamide, and helps you achieve a good night’s sleep by reducing muscle tension, reducing restlessness and anxiety, and by supporting a normal pattern of REM sleep. It also reduces the perception of pain and may help if aches and pains are keeping you awake.

“Ever since I started taking a capsule at night I’ve slept really deeply and woken feeling refreshed. While some people experience vivid dreams when taking CBD, I now sleep so heavily that I rarely recall my dreams.”

But she notes: “If you have a health condition or are taking any prescribed or over-the-counter medicines, always check with your doctor or a pharmacist before taking CBD, as it interacts with enzymes involved in metabolising some medicines. Many doctors and pharmacists feel unable to advise on this, however.

“The best Drug Interaction checker I have found is on Drugs.com, which includes most herbs, supplements and prescribed medicines. While it does not specifically include CBD it does include cannabis (which as well as containing CBD also includes the legally-regulated, psychoactive ingredient, THC).”

Best supplements for sleep: Six natural remedies could ensure a good night’s rest (Image: GETTY)


Magnesium is a mineral that is involved in the synthesis of melatonin hormone, which helps to program your sleep-wake cycle, says Dr Brewer. She added: “Magnesium also has a relaxing effect on muscles and helps to prevent restless legs – an annoying jerking of the lower limbs which can stop you from drifting off. A study involving 46 older people with sleep problems showed that taking 500 mg magnesium a day for eight weeks significantly improved melatonin levels, sleep time and reduced early morning waking compared with placebo. It helped those taking magnesium gain an extra 18 minutes of sleep (7.9 hours versus 7.6 hours).

“When taken by mouth, magnesium supplement can have a laxative effect at doses above 400mg per day which is not always a bad thing – taking a magnesium supplement at night helps to promote regularity next morning. I take Healthspan Opti-Magnesium (which I helped to formulate) which is less likely to produce this effect, and can easily be taken in a half dose. Other options include absorbing magnesium through the skin (eg BetterYou magnesium Oil Spray) or have a relaxing bath containing magnesium salts.”


Valerian is a traditional herbal remedy that both reduces anxiety and improves sleep quality, and it appears to have a similar effect to a calming brain chemical called gamma-aminobutyric acid (GABA).

Dr Brewer said: “This reduces anxiety and restlessness, and induces calm so you achieve a deeper level of sleep more quickly. Valerian is also helpful for women whose sleep disturbance is linked with the menopause. A large analysis of data from 18 studies, involving over 1,300 people with sleep difficulties found that valerian significantly improved sleep quality by 37 per cent compared with inactive placebo.

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“When valerian was compared with the prescribed tranquiliser, oxazepam, it was at least as effective for increasing sleep quality, duration of sleep, dream recall, waking feeling refreshed and reducing evening exhaustion. Valerian was less likely to cause side effects, however and, unlike oxazepam, does not have any potential for addiction.

“The combination of valerian and hops has a synergistic sedative effect, and in one study allowed participants spend a significant longer periods asleep, including longer periods in refreshing deep sleep after a single dose eg A.Vogel Dormeasan Valerian-Hops Sleep Remedy which is available in the form of a tincture. It tastes bitter, so mix with fruit juice. My other half swears by Dormeasan and takes it every night.

“Valerian is also available combined with Passion Flower in Schwabe Pharma’s Bonuit Sleep Aid, which is an herbal medicine licensed for the relief of sleep disturbances due to mild anxiety.”

Lavender oil

Lavender is well-known for its sedative effect and is often used in pillows and as an aromatherapy oil to improve sleep quality. Dr Brewer said: “Lavender oil capsules are now also licensed as a traditional herbal medicine to relieved symptoms of mild anxiety, such as stress and nervousness, which can interfere with sleep. For safe oral use, the oil must come from the flowers of one particular species of lavender and be prepared to pharmaceutical standards (eg Kalms Lavender One-A-Day).

“Lavender is especially helpful when sleep difficulties are due to anxiety. Brain scan studies show that lavender oil works by raising levels of serotonin and other brain neurotransmitters involved in regulating mood and anxiety. Clinical trials show that lavender oil is as effective as the prescription-only tranquiliser, lorazepam, for relieving anxiety, bit without the side effects or potential for addiction. The main side effect is flatulence (but at least your wind smells nice!)”

Best supplements for sleep: Lavender oil is well-known for its sedative effect (Image: GETTY)

Best supplements for sleep: Valerian is a traditional herbal remedy (Image: GETTY)

Cherry extracts

Cherry juice is one of the richest dietary sources of pre-formed melatonin sleep hormone, according to Dr Brewer. She added: “The level of melatonin present in sour cherries is at least five times greater than is found in other dietary sources such as blackberries and strawberries. Cherries also contain tryptophan, an essential amino acid needed for the synthesis of melatonin, while the dark red cherry pigments boost the uptake of tryptophan, to magnify its effects.

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“In a UK study involving 20 volunteers drank tart cherry juice concentrate or placebo for 7 days. Melatonin levels rose significantly in those drinking the cherry juice, along with total sleep time and sleep efficiency, while no changes were seen with placebo.

“Researchers from Louisiana State University found that drinking Montmorency cherry juice increases the amount of time you spend asleep. in fact, those with insomnia who drank cherry juice twice a day, for two weeks, slept over an hour longer each night (averaging 84 minutes) compared with placebo e.g Healthspan Super Cherry juice concentrate.”

5-hydroxytryptophan (5-HTP) is a unique amino acid that’s only found in two places in nature – the human body and in the seeds of a West African medicinal plant, Griffonia simplicifolia from which supplements are derived.

Dr Brewer explained: “5-HTP acts as a building block to make brain chemicals including serotonin and melatonin sleep hormone. Studies show that 5-HTP helps you fall asleep more quickly, and extends the length of time spent in REM (rapid eye movement, or dreaming) sleep, so you wake up feeling more refreshed. 5-HTP is especially helpful for people with fibromyalgia, in which widespread pains, fatigue and sleep disturbance have been linked with low levels of serotonin.”

Dr Sarah Brewer has a master’s degree in Nutritional Medicine and is the Medical Director of Healthspan. www.DrSarahBrewer.com.

Important: If taking any prescribed medication, always check for interactions before taking any supplement, especially herbal supplements.

Can I Take CBD and Magnesium Together?

CBD, short for cannabidiol, is used as an adjunctive treatment for a variety of health problems, including pain and inflammation. It has a very good safety profile in most illnesses.

Magnesium is an essential mineral that can be beneficial for treating migraines, hypertension, bone density loss, and more.

Since both compounds use different mechanisms of action, there’s very little chance that negative interactions will occur.

As of today, there are no reports with complaints about taking CBD and magnesium together.

In this article, we provide a general breakdown of the dos and don’ts of CBD and magnesium supplementation.

Does CBD Interact with Magnesium?

No, there’s no evidence supporting any kind of interactions caused by taking CBD and magnesium together.

Certain conditions call for a higher intake of magnesium for only a short period, so the chances of interactions between the two substances reaching toxic levels in the blood are extremely low.

However, if you want to take CBD and magnesium in tandem, you should still do it with caution. Magnesium may impact the absorption of CBD in the digestive system, thus compromising its efficacy.

To avoid this potential side effect, it’s best to take magnesium supplements around 2 hours apart from your CBD oil.

Can CBD be a Good Alternative to Magnesium?

I wouldn’t consider it in that manner because CBD and magnesium are completely different supplements.

Magnesium is a crucial mineral used in more than 300 enzymatic processes in our bodies. CBD is a cannabinoid extracted from hemp and interacts with the human endocannabinoid system (ECS) — our major regulatory network that promotes and helps maintain homeostasis.

For most applications, you can’t use CBD instead of magnesium. You can however use CBD for certain medical conditions that magnesium is also recommended for.

If you suffer from a magnesium deficiency, CBD won’t solve the problem, but if the root cause of your health problems is somewhere else, CBD may significantly assist you in treating these conditions more than magnesium supplements.

Given this, it’s better to include both supplements in your daily routine to achieve a more holistic effect than if you took either one individually.

Just make sure not to take them at the same time — this is to enable maximum absorption of both compounds.

You can take CBD and magnesium to ease the following health conditions:

CBD vs Magnesium for Migraine Headaches

Magnesium is the go-to supplement for treating migraine headaches. Many people with migraines have low levels of magnesium, so adding this supplement can lower your migraine headaches.

CBD has also been highlighted as an effective treatment for migraines and other forms of headaches, including cluster headaches and hangovers.

While it’s unlikely that CBD alone will prevent or erase your migraines, it may reduce the duration and severity of these attacks — not to mention concomitant problems like insomnia, nausea, vomiting, and sleep disturbances.

CBD vs Magnesium for Depression & Anxiety

Again, patients with depression usually have low magnesium scores on their tests, so supplementing it can alleviate the symptoms and help enhance mood in depressive patients.

CBD acts on the 5-HT1A neuro-receptors in the brain, which helps the body use serotonin more efficiently and thus produce an anxiolytic and antidepressant effect.

CBD vs Magnesium for Cardiovascular Diseases

Magnesium has been proven to decrease the risk of getting a stroke, ischemic and coronary heart disease, metabolic disorders, and hypertension.

In one study, CBD demonstrated remarkable antioxidative properties, translating into better cardiac function. Its anti-inflammatory effects also help reduce the risk of cardiac diseases.

CBD vs Magnesium for Insomnia

Magnesium can regulate the neurotransmitters directly related to the brain, hence the potential in treating insomnia.

CBD may also improve sleep on top of helping regulate the sleep-wake cycle and is more tolerated than conventional sleeping pills.

CBD vs Magnesium for Type 2 Diabetes

If you want to ensure the proper breakdown of glucose in the body, you need to control your magnesium levels. Having a good amount of magnesium in the diet may help prevent type 2 diabetes.

CBD can offer metabolic support as well. These properties stem from the cannabinoid’s interaction with the ECS. The ECS is strongly related to liver and pancreas health — both of which are mentioned in the pathophysiology of diabetes.

CBD vs Magnesium for Bone Health

When your body lacks magnesium, it can further create problems with bone health, namely osteoporosis in the body. To prevent this condition, dieticians recommend supplementing with magnesium. It’s one of the most popular supplements for menopausal women for this reason.

Again, with CBD, it’s the interaction with the endocannabinoid system that improves bone health by increasing bone density and reducing inflammation in the body.

CBD vs Magnesium for Epilepsy

Seizures caused by conditions related to pregnancy like eclampsia can be treated with magnesium sulfate, a compound containing magnesium. It’s a common supplement in magnesium-deficient people.

CBD-based medications, such as Epidiolex and Satives, are approved to treat a wide range of seizure disorders thanks to their anticonvulsant and antispasmodic properties.

What is Magnesium?

Magnesium is among the essential macrominerals that we need to survive and thrive in good health. It can be obtained from different kinds of foods, supplements, and even medications.

The most common indication for taking magnesium supplements is magnesium deficiency, but it can also be prescribed for problems like constipation, arrhythmias, heartburn, pre-eclampsia, eclampsia, and more.

Magnesium engages in more than 300 unique enzymatic reactions within the body. They range from liver metabolism to cellular replication and hundreds of different processes in between.

Your muscles and nerves, blood pressure, immune function, bone health — these are just some of the essential functions that magnesium can help control.

Magnesium Highlights

Names Magnesium, magnesium carbonate, magnesium citrate, magnesium chloride, magnesium malate, magnesium sulfate, magnesium oxide
Classification Essential Macromineral
Metabolism Kidneys, digestive system
Interaction with CBD Very unlikely
Risk of Interaction Low

What Does Magnesium Do for the Body

The body needs magnesium to properly manage several physiological functions.

It’s distributed to the soft tissue, skeletal muscle, bones, and extracellular fluids. The regulation of magnesium levels occurs through an interaction between absorption by the bone, intestinal absorption, and renal absorption (or excretion).

Magnesium facilitates ion transport and helps maintain the balance across cellular membranes. It also controls the uptake and release of calcium, controlling its metabolism as the calcium channel competitor.

The mineral also can induce muscle relaxation and reduce spasms by stopping the contraction caused by calcium in the smooth muscles and acetylcholine’s actions on the junctions between the muscle and nerves.

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Magnesium supports over 300 enzymes in triggering different processes in the body. It also contributes as a cofactor to enzymatic actions in various bodily activities — from building proteins to regulating glucose levels to building bones, controlling blood pressure, and maintaining muscles and nerves in a good condition.

Another aspect of your health that can benefit from magnesium supplementation is the actions of N-methyl-D-aspartate (NMDA) glutamate receptors, which are required for learning and memory formation.

Overactive glutamate in the brain can lead to anxiety, depression, and seizures. Magnesium can block the action of glutamate in the NMDA receptors — potentially preventing or treating depression.

Symptoms of Magnesium Deficiency

If you have a magnesium deficiency, you may experience the following symptoms:

  • Muscle cramps
  • Tingling
  • Nausea
  • Vomiting
  • Headaches
  • Numbness

Magnesium can be used to treat cardiac arrhythmias resulting from hypomagnesemia, seizures triggered by eclampsia, constipation, heartburn, migraines, and nephritis.

Side Effects of Magnesium

Despite a decent safety profile, too much magnesium taken for a long period — such as 350 mg daily — can cause dangerous buildups that are responsible for many nasty side effects, such as:

  • Stomach upset
  • Nausea
  • Vomiting
  • Diarrhea
  • Facial flushing
  • Low blood pressure
  • Tingling sensation
  • Weakness
  • Overactive reflexes
  • Fatigue
  • Confusion
  • Slowed Breathing
  • Muscle depression
  • Coma

3 Drug Interactions with CBD

Several studies demonstrated that CBD is effective in treating a wide range of symptoms and diseases.

However, like most other therapeutic substances, it can interact with other medications when administered together.

These effects occur due to the chemical nature of these supplements. Therefore, taking CBD with other drugs should be carefully monitored by your doctor.

There are three mechanisms that CBD uses to interact with other drugs, including:

1. Agonistic Interaction

This type of interaction means that two compounds show the same effect in the body. When taken together, they act on the same or different receptors. However, their effects have the same directions.

Medications that can enter agonistic interactions with CBD are:

  • Antihypertensive Medications – such as alpha-blockers, beta-blockers, angiotensin II receptor blockers, ACE inhibitors, calcium channel blockers, central agonists, and diuretics. CBD can interact with these drugs causing a drop in blood pressure, lightheadedness, and fainting.
  • Anti-anxiety Medications – such as benzodiazepines and barbiturates. CBD could extend the duration of these medications.
  • Antidiabetic Medications – such as GLP-1 receptor agonists, SGLT-2 inhibitors, DPP-4 inhibitors, meglitinides, sulfonylureas, insulin, alpha-glucosidase inhibitors, and biguanides

2. Antagonistic Interaction

This works in an opposite way to the agonistic interaction.

Antagonistic interactions occur when two drugs have opposite effects on each other. When taken together, one compound may invalidate the effects of the other, lowering its efficacy.

Examples of antagonistic CBD-drug interactions include:

  • Stimulants – drugs like amphetamine and modafinil. CBD can inhibit the effects of these drugs.
  • Immunomodulators – including antihistamines like carbinoxamine, levocetirizine, and desloratadine. The sedative properties of CBD could make the side effects of immunomodulators worse.
  • Immunosuppressants – such as azathioprine, mycophenolate, methotrexate, cyclosporine, etc. CBD’s immuno-modulating properties may weaken the effects of immunosuppressants.
  • Asthma medications – drugs like fluticasone, ipratropium bromide, montelukast, albuterol, and theophylline. CBD may mitigate the actions of these drugs and speed up their excretion from the body.

3. Metabolic Inhibition

Some meds require similar enzymes to metabolize the drug molecules. It results in competition between both drugs; they act against each other and cause a slowdown in the metabolic rate of both drugs.

Medications prone to metabolic inhibition when taken with CBD include:

  • Blood Thinners – CBD could increase the concentration of warfarin, enoxaparin, heparin, and other anticoagulants.
  • NSAIDs – drugs like ibuprofen and naproxen interact with CBD and thus could last longer in the bloodstream.
  • Opiate Painkillers – such as morphine, codeine, and hydrocodone. CBD competes with them in the liver, theoretically increasing the chance of overdose.
  • Antidepressants – drugs like trazodone, mirtazapine, vortioxetine, and vilazodone. CBD can inhibit their breakdown and cause the buildup of these drugs in the body.

Final Thoughts on Interactions Between CBD and Magnesium

CBD and magnesium use completely different mechanisms and, in theory, shouldn’t interact with one another.

However, there are no proper clinical trials and studies examining the potential interactions, nor do we have reported documentation of the side effects by users who have taken them in conjunction.

If you regularly use magnesium and want to add CBD to boost its benefits for a specific health disorder, you should consult it with your doctor before buying any CBD product.

However, if you take both supplements for the sole purpose of supplementation, there’s little to no risk of using CBD and magnesium together.

Just make sure to leave a 1- or 2-hour window between each dose; otherwise, magnesium may negatively impact the absorption rate of CBD in the digestive system.

If you experience any adverse reactions after taking CBD and magnesium, stop using them and wait for a few days to see if the symptoms are gone. If they persist, visit your doctors to figure out the potential cause.


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Nina Julia

Nina created CFAH.org following the birth of her second child. She was a science and math teacher for 6 years prior to becoming a parent — teaching in schools in White Plains, New York and later in Paterson, New Jersey.

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