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Synthetic cannabis deaths sound alarms in Australia Compounds a chemistry graduate student could make are taking a toll worldwide 14 Jan. 2015 By Dennis Normile The deaths of An AP investigation shows that a troubling number of CBD products are spiked with synthetic marijuana, which can cause comas, psychotic behavior, and death. Synthetic cannabinoids have caused a large number of emergency presentations to hospitals for adverse cardiovascular events including numerous deaths, particularly for the more potent analogs acting on the CB<sub>1</sub> receptor. While smoked cannabis use is often associated with significant change …

Synthetic cannabis deaths sound alarms in Australia

Compounds a chemistry graduate student could make are taking a toll worldwide

  • 14 Jan. 2015
  • By Dennis Normile

The deaths of two men—one yesterday and one today—and a rash of recent hospitalizations in Australia, all suspected to result from the use of synthetic cannabis, are focusing attention on a growing worldwide problem.

Drug users have been embracing products touted as producing a natural marijuanalike high. The effect is produced by synthetic compounds designed to mimic THC, the active ingredient in marijuana, which are sprayed onto plant material then often marketed as “Spice.” However, “synthetic cannabinoids certainly have the potential to be significantly more dangerous than the natural plant material that they supposedly mimic,” says David Caldicott, an emergency medical doctor at the Australian National University in Canberra.

The compounds were originally designed to study the neurobiology of cannabis in animals. They were never intended for human use. But “these drugs aren’t too difficult to synthesize,” says Richard Kevin, a psychopharmacology Ph.D. candidate at the University of Sydney in Australia who is studying the effects of the synthetic compounds on mice. He says a competent chemistry grad student could cook them up in a university lab. So a worldwide cottage industry has sprung up producing synthetic cannabis. But with no standards, no regulation, and no quality control, there is “a large variety of synthetic cannabinoids with largely unknown toxicity,” Kevin says. And “because they are simply sprayed onto whatever carrier plant material is chosen,” Caldicott says, “hot spots can occur where the concentration is higher than intended.”

Haphazard production has led to particularly toxic batches and clusters of poisoning. According to news reports , synthetic cannabis use killed 25 and sickened more than 700 in northern Russia alone last fall.

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Kevin says one reason people use these products is to foil drug testing. Although the synthetic cannabis targets the same brain regions as THC, the molecular structures are different and escape detection by standard drug tests. Australian states have outlawed drugs that mimic cannabis. But proving cannabislike effects of any particular compound “can be tricky,” Kevin says. And to keep ahead of the law and drug testing, makers are constantly tweaking their recipes. “The rate of evolution of these drugs is such that many have never been seen before,” Caldicott says.

When buying synthetic cannabis, “you can’t know exactly what you’re getting, so you’re taking a big risk,” Kevin says. He says that although some synthetic cannabinoids appear to be relatively well tolerated, others have been linked to acute kidney injury, panic attacks, and seizures. His own studies with mice suggest “long-term memory impairment after heavy chronic dosing.”

“We need wittier and wiser responses to the problem of harm from drugs if these deaths are not to become a more frequent occurrence,” Caldicott says.

Some CBD Tainted With Substance That Causes Death, Comas, Insanity

Thanks to patchwork regulation, a number of CBD products contain stuff that could cause a psychotic episode — or even kill you.

A troubling trend: vapes and other products advertised as containing CBD are actually spiked with synthetic marijuana, a dangerous drug that’s been linked with deaths, serious hospitalizations, and psychosis.

Poring over a collection of police records and the findings of its own investigation into CBD products, The Associated Press found that many products labeled as CBD products only contain trace amounts of the chemical, which advocates claim treats a range of medical maladies.

But many contained dangerous synthetic marijuana — and tracking down the perpetrators meant leaping down a rabbit hole of weak government regulations and shady business practices.

In a separate report, the AP found that 128 of the 350 CBD products tested by American law enforcement agencies contained synthetic marijuana, as did ten of the 30 tested by the AP.

“It’s Russian roulette,” James Neal-Kababick told the AP. He’s the director of Flora Research Laboratories, which the AP commissioned to run the tests CBD products. Synthetic marijuana poses an ongoing problem that’s unrelated to recent cases of a mysterious “vape lung” illness.

The AP also profiled cases like one in which a college student fell into a coma after two hits of a spiked CBD vape. In Utah, that same brand hospitalized 33 people. In another case, an eight-year-old boy was hospitalized when his parents tried to treat his seizures with spiked CBD oil. In Europe, the synthetic marijuana that popped up in the AP‘s investigation has killed 11. In those and other cases investigated by the AP, the products’ packaging made no mention of synthetic marijuana.

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The FDA is in charge of regulating CBD because it’s approved at least one pharmaceutical that uses the drug as an active ingredient. A spokesperson told the AP that if synthetic marijuana is found in a product, it becomes the DEA’s problem. But a DEA spokesperson told the AP that synthetic marijuana is a low priority for the agency.

“As long as it remains unregulated like it currently is,” Virginia Commonwealth University researcher Michelle Peace told the AP, “you just give a really wide space for nefarious activity to continue.”

Cannabis as a cause of death: A review

Synthetic cannabinoids have caused a large number of emergency presentations to hospitals for adverse cardiovascular events including numerous deaths, particularly for the more potent analogs acting on the CB1 receptor. While smoked cannabis use is often associated with significant changes in heart rate and cardiac output, amongst other physiological changes, it has been rarely considered in the forensic literature as a significant contributory or causal factor in sudden unexpected death. A review of case reports of admissions to hospitals for cardiovascular events was undertaken together with a review of epidemiological studies, and case reports of sudden death attributed, at least in part, to use of this drug. These publications show that use of cannabis is not without its risks of occasional serious medical emergencies and sudden death, with reports of at least 35 persons presenting with significant cardiovascular emergencies who had recently smoked a cannabis preparation. At least 13 deaths from a cardiovascular mechanism have been reported from use of this drug which is very likely to be an under-estimate of the true incidence of its contribution to sudden death. In addition, many cases of stroke and vascular arteritis have also been reported with the latter often involving a limb amputation. While it is a drug with widespread usage among the community with relatively few deaths when faced with a circumstance of very recent use (within a few hours), a positive blood concentration of THC and a possible cardiac-related or cerebrovascular cause of death this drug should be considered, at least, a contributory cause of death in cases of sudden or unexpected death.

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Keywords: Arrhythmias; Cardiovascular disease; Forensic; Heart disease; Myocardial infarction; Stroke.

Copyright © 2019 Elsevier B.V. All rights reserved.

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